The anatomical findings described above suggest that BG microglia exhibit regional variation in functional state even in the absence of pathology. These findings demonstrate that microglia in the healthy brain exhibit a spectrum of distinct functional states and provide a critical foundation for defining microglial contributions to BG circuit function. Region-specific phenotypes of BG microglia emerged during the second postnatal week and were re-established following genetic or pharmacological microglial ablation and repopulation in the adult, indicating that local cues play an ongoing role in shaping microglial diversity. Here, we show that microglial anatomical features, lysosome content, membrane properties, and transcriptomes differ significantly across BG nuclei. However, little is known about basic properties of deep brain microglia, such as those within the basal ganglia (BG). In contrast to astrocytes and oligodendrocytes, which arise from multiple progenitor pools, microglia arise from yolk sac progenitors and are widely considered to be equivalent throughout the CNS. On-demand webinar: Harnessing insight from real-world oncology cases : introducing HSMD – In this on-demand webinar, we will introduce you to the Human Somatic Mutation Database (HSMD)-a new somatic database developed by QIAGEN.Microglia play critical roles in tissue homeostasis and can also modulate neuronal function and synaptic connectivity.On-demand Webinar: How you can simplify your NGS secondary analysis workflow to 5 easy steps – Find out how you can simplify your NGS secondary analysis workflow to 5 easy steps using QCI Secondary Analysis, a new cloud-based service f.On-demand webinar: Discover hidden relationships in your toxicological studies with QIAGEN IPA – Watch this informative past webinar on how QIAGEN IPA can help you dig deeper into your toxicogenomic studies!.23 – This training will focus on using IPA and HSMD to identify key somatic variants associated with regulatory genes in ‘omic data. Somatic variants investigation in context of critical regulatory pathways and networks – Aug.16 – Join us in this training to learn how to locate public single-cell studies of their interest using Omicsoft Single Cell Lands. Public single cell RNA-seq data investigation using Omicsoft and Ingenuity Pathway Analysis – Aug. 09 – Join us for a 90-minute training session for new users of QIAGEN IPA. QIAGEN Ingenuity Pathway Analysis (IPA) New user trainings – All Regions – Jul.QIAGEN OmicSoft – Powerful cloud-enabled ‘omics GUI, complete NGS analysis workflows and unparalleled curated content for immediate exploration.Human Somatic Mutation Database (HSMD) – A new somatic database developed by QIAGEN that contains extensive genomic content relevant to solid tumors and hematological malignancies.QIAGEN IPA – Powerful tools to uncover the significance of data and identify new targets or candidate biomarkers within the context of biological systems.Introducing QCI Interpret One, clinical decision support software with professional i. QCI Interpret One – Oncology variant interpretation just got more precise.Catalogue of Somatic Mutations in Cancer (COSMIC) – Explore the impact of somatic mutations in human cancer with the world’s largest and most comprehensive resource.Clinical Analysis and Interpretation Services.Pharmaceutical Development Bioinformatic Services.QIAGEN Discovery Bioinformatics Services.QIAGEN CLC Genomics Workbench – QIAGEN CLC Genomics Workbench is a powerful solution that works for everyone, no matter the workflow.Human Gene Mutations Database (HGMD) – Solve more cases faster, with data you can trust using HGMD Professional, the gold standard for identifying inherited disease-causing mutati.QIAseq panels | QIAGEN Digital Insights.Clinical QKB (Clinical QIAGEN Knowledge Base).COSMIC (Catalogue of Somatic Mutations in Cancer).Learn more about its role in oncogenesis and ac. Know your biomarkers: PRKD1 linked to head and neck cancer? – A new cancer gene, PRKD1, has been identified as defining a subset of head and neck cancers.Stop looking for a needle in a haystack – Easily accelerate biomarker and target discovery by exploring and interpreting your data with intuitive, visual biomarker identification too.Single-Cell Genomic Solutions – Explore our powerful solutions for the analysis and interpretation of single-cell gene expression analysis and genomics.Pharmaceutical Development – Whether searching for clinically applicable biomarkers, designing a new companion diagnostic (CDx), or honing your study accrual and go-to-m.Research & Discovery – Powerful digital insights to help you innovate, integrate and translate scientific results into impactful discoveries.
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